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Validating the EMCV IRES Secondary Structure with Structure–Function Analysis

11 Dec 2023

Abstract excerpt

The encephalomyocarditis virus internal ribosome entry site (EMCV IRES) is a structured RNA sequence found in the 5′ UTR of the genomic RNA of the encephalomyocarditis virus. The EMCV IRES structure facilitates efficient translation initiation without needing a 5′ m 7 G cap or the cap-binding protein eIF4E. The secondary structure of IRES has been the subject of several previous studies, and a number of different...

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PMID: 38081770
DOI: 10.1021/acs.biochem.3c00579

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