Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mechanistic role of structurally dynamic regions in Dicistroviridae IGR IRESs.

Journal of molecular biology - 8 Jan 2010

Pfingsten Jennifer S, Castile Alice E, Kieft Jeffrey S

Abstract excerpt

Dicistroviridae intergenic region (IGR) internal ribosome entry site(s) (IRES) RNAs drive a cap-independent pathway of translation initiation, recruiting both small and large ribosomal subunits to viral RNA without the use of any canonical translation initiation factors. This ability is conferred by the folded three-dimensional structure of the IRES RNA, which has been solved by X-ray crystallography. Here, we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Crystallography, X-Ray
Share to DNA, Intergenic
Share to Models, Molecular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Nucleic Acid Conformation

Share to Pliability

Share to Protein Biosynthesis

Share to Protein Structure, Tertiary

Share to Ribosomes

Source

Open in PubMed Open full text

Identifiers

PMID: 19878683
DOI: 10.1016/j.jmb.2009.10.047
PMCID: PMC2788014

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mechanistic role of structurally dynamic regions in Dicistroviridae IGR IRESs.PMID 19878683Read ↗

Structural basis for ribosome recruitment and manipulation by a viral IRES RNA.Semantic proximity Read ↗

Structural methods for studying IRES function.Semantic proximity Read ↗

Conserved element of the dicistrovirus IGR IRES that mimics an E-site tRNA/ribosome interaction mediates multiple functions.Semantic proximity Read ↗

Structural determinants of an internal ribosome entry site that direct translational reading frame selection.Semantic proximity Read ↗

Validating the EMCV IRES Secondary Structure with Structure–Function AnalysisSemantic proximity Read ↗

The Hinge Region of the Israeli Acute Paralysis Virus Internal Ribosome Entry Site Directs Ribosomal Positioning, Translational Activity, and Virus Infection.Semantic proximity Read ↗

Minimum internal ribosome entry site required for poliovirus infectivity.Semantic proximity Read ↗

Functional Insights into the Adjacent Stem-Loop in Honey Bee Dicistroviruses That Promotes Internal Ribosome Entry Site-Mediated Translation and Viral InfectionSemantic proximity Read ↗

Activity of the human immunodeficiency virus type 1 cell cycle-dependent internal ribosomal entry site is modulated by IRES trans-acting factorsSemantic proximity Read ↗

Binding of a viral IRES to the 40S subunit occurs in two successive steps mediated by eS25.Semantic proximity Read ↗

The hepatitis C virus internal ribosome entry site adopts an ion-dependent tertiary fold.Semantic proximity Read ↗

Understanding the potential of hepatitis C virus internal ribosome entry site domains to modulate translation initiation via their structure and functionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.