Article
Directionality of wingless protein transport influences epidermal patterning in the Drosophila embryo.
Development (Cambridge, England) - 1 Oct 1999
Moline M M, Southern C, Bejsovec A
Abstract excerpt
Active endocytotic processes are required for the normal distribution of Wingless (Wg) protein across the epidermal cells of each embryonic segment. To assess the functional consequences of this broad Wg distribution, we have devised a means of perturbing endocytosis in spatially restricted domains within the embryo. We have constructed a transgene expressing a dominant negative form of shibire (shi), the fly...
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