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Article

Ligand endocytosis drives receptor dissociation and activation in the Notch pathway.

Development (Cambridge, England) - 1 Apr 2000

Parks A L, Klueg K M, Stout J R, Muskavitch M A

Abstract excerpt

Endocytosis of the ligand delta; is required for activation of the receptor Notch during Drosophila development. The Notch extracellular domain (NotchECD) dissociates from the Notch intracellular domain (NotchICD) and is trans-endocytosed into delta;-expressing cells in wild-type imaginal discs. Reduction of dynamin-mediated endocytosis in developing eye and wing imaginal discs reduces Notch dissociation and...

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Source

Identifiers

PMID: 10704384
DOI: 10.1242/dev.127.7.1373

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Ligand endocytosis drives receptor dissociation and activation in the Notch pathway.PMID 10704384Read ↗

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Either part of a Drosophila epsin protein, divided after the ENTH domain, functions in endocytosis of delta in the developing eye.Semantic proximity Read ↗

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