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Article

Nuclear localization signal recognition causes release of importin-alpha from aggregates in the cytosol.

Journal of molecular biology - 17 Sept 1999

Percipalle P, Butler P J, Finch J T, Jans D A, Rhodes D

Abstract excerpt

Importin-alpha is a cytosolic receptor that recognizes classical Nuclear Localization Signals (NLSs) and mediates import into the nucleus. We have used a number of methods to investigate the aggregation state of Xenopus importin-alpha both as a recombinant, purified protein and in cytosolic extracts. We have found that recombinant importin-alpha aggregates at a protein concentration similar to that estimated to...

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Identifiers

PMID: 10493874
DOI: 10.1006/jmbi.1999.3077

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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