Article
Characterization of the auto-inhibitory sequence within the N-terminal domain of importin alpha.
The Journal of biological chemistry - 13 Jun 2003
Harreman Michelle T, Cohen Pamela E, Hodel Mary R, Truscott Glyn J, Corbett Anita H, Hodel Alec E
Abstract excerpt
Protein cargoes that contain a classic nuclear localization signal (NLS) are transported into the nucleus through binding to a heterodimeric receptor comprised of importin/karyopherin alpha and beta. An evolutionarily conserved auto-inhibitory sequence within the N-terminal importin beta binding...
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