Article
Dissection of a nuclear localization signal.
The Journal of biological chemistry - 12 Jan 2001
Hodel M R, Corbett A H, Hodel A E
Abstract excerpt
The regulated process of protein import into the nucleus of a eukaryotic cell is mediated by specific nuclear localization signals (NLSs) that are recognized by protein import receptors. This study seeks to decipher the energetic details of NLS recognition by the receptor importin alpha through quantitative analysis of variant NLSs. The relative importance of each residue in two monopartite NLS sequences was...
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