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Article

Structural basis of recognition of monopartite and bipartite nuclear localization sequences by mammalian importin-alpha.

Journal of molecular biology - 14 Apr 2000

Fontes M R, Teh T, Kobe B

Abstract excerpt

Importin-alpha is the nuclear import receptor that recognizes cargo proteins which contain classical monopartite and bipartite nuclear localization sequences (NLSs), and facilitates their transport into the nucleus. To determine the structural basis of the recognition of the two classes of NLSs by mammalian importin-alpha, we co-crystallized an N-terminally truncated mouse receptor protein with peptides...

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Identifiers

PMID: 10764582
DOI: 10.1006/jmbi.2000.3642

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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