Article
Classical NLS proteins from Saccharomyces cerevisiae.
Journal of molecular biology - 13 Jun 2008
Hahn Silvia, Maurer Patrick, Caesar Stefanie, Schlenstedt Gabriel
Abstract excerpt
Proteins can enter the nucleus through various receptor-mediated import pathways. One class of import cargos carries a classical nuclear localization signal (cNLS) containing a short cluster of basic residues. This pathway involves importin alpha (Impalpha), which possesses the cNLS binding site, and importin beta (Impbeta), which translocates the import complex through the nuclear pore complex. The defining...
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