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Article

Cellular responses to radiation and risk of breast cancer.

European journal of cancer (Oxford, England : 1990) - 1 Apr 1999

Jongmans W, Hall J

Abstract excerpt

Mutations in the ataxia telangiectasia gene (ATM) result in an abnormal p53-mediated cellular response to DNA damage produced by ionising radiation. This deficiency is believed to contribute to the radiosensitivity and high cancer risk seen in ataxia telangiectasia (AT) patients and AT heterozygotes. Epidemiological studies have demonstrated that relatives of AT patients are particularly predisposed to breast...

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Source

Identifiers

PMID: 10492625
DOI: 10.1016/s0959-8049(98)00414-6

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

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Cellular responses to radiation and risk of breast cancer.PMID 10492625Read ↗

The role of ATM in breast cancer development.Semantic proximity Read ↗

ATM, radiation, and the risk of second primary breast cancer.Semantic proximity Read ↗

The ATM gene and breast cancer: is it really a risk factor?Semantic proximity Read ↗

ATM haplotypes and cellular response to DNA damage: association with breast cancer risk and clinical radiosensitivity.Semantic proximity Read ↗

Workshop on The Epidemiology of the ATM Gene: Impact on Breast Cancer Risk and Treatment, Present Status and Future Focus, Lillehammer, Norway, 29 June 2002.Semantic proximity Read ↗

ATM and breast cancer susceptibility.Semantic proximity Read ↗

Functional consequences of ATM sequence variants for chromosomal radiosensitivity.Semantic proximity Read ↗

Severe reaction to radiotherapy for breast cancer as the presenting feature of ataxia telangiectasia.Semantic proximity Read ↗

Radiation exposure, the ATM Gene, and contralateral breast cancer in the women's environmental cancer and radiation epidemiology study.Semantic proximity Read ↗

Chromosomal radiosensitivity, cancer predisposition and response to radiotherapy.Semantic proximity Read ↗

Clinical radiosensitivity in breast cancer patients carrying pathogenic ATM gene mutations: no observation of increased radiation-induced acute or late effectsSemantic proximity Read ↗

Radiotherapy and genetic predisposition to breast cancer.Semantic proximity Read ↗

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