Article
Severe reaction to radiotherapy for breast cancer as the presenting feature of ataxia telangiectasia.
British journal of cancer - 17 Jan 2012
Byrd P J, Srinivasan V, Last J I, Smith A, Biggs P, Carney E F, Exley A, Abson C, Stewart G S, Izatt L, Taylor A M
Abstract excerpt
BACKGROUND: Severe early and late radiation reaction to radiotherapy is extremely rare in breast cancer patients. Such a reaction prompted an investigation into a 44-year-old mother (patient A-T213). METHODS: A neurological examination was performed and blood lymphocytes and skin fibroblasts were assessed for radiosensitivity chromosomally and by colony-forming assay. The ATM gene was sequenced and ATM mutations...
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