Article
Mutated ras p21 as a target for cancer therapy in mouse transitional cell carcinoma.
The Journal of urology - 1 Oct 1999
Luo Y, Chen X, Han R, Chorev M, Dewolf W C, O'Donnell M A
Abstract excerpt
PURPOSE: To establish an experimental mouse model for bladder cancer immunotherapy using mutated ras as a target. MATERIALS AND METHODS: A tumorigenic mouse bladder transitional cell carcinoma (TCC) line MB49 (C57BL/6 origin) was analyzed for its c-ras gene status by DNA cloning and sequencing. Aberrant expression of the ras gene was measured with Western blotting. 13-mer peptides corresponding to residues 5 to...
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