Subunit peptide cancer vaccines targeting activating mutations of the p21 ras proto-oncogene.

Abstract excerpt

Activating mutations of the p21 ras proto-oncogene are involved in the development of many common malignancies. Because activating mutations are limited in number, occur within otherwise completely conserved regions, and can be expressed by premalignant lesions, ras is an attractive target for subunit peptide vaccine approaches. Several studies in transplantable tumor models support the possibility that...

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