Article
Subunit peptide cancer vaccines targeting activating mutations of the p21 ras proto-oncogene.
Biomedical peptides, proteins & nucleic acids : structure, synthesis & biological activity - 1 Jan 1995
Triozzi P L, Stoner G D, Kaumaya P T
Abstract excerpt
Activating mutations of the p21 ras proto-oncogene are involved in the development of many common malignancies. Because activating mutations are limited in number, occur within otherwise completely conserved regions, and can be expressed by premalignant lesions, ras is an attractive target for su...
Topics
- Amino Acid Sequence
- Animals
- Cancer Vaccines
- Disease Models, Animal
- Dose-Response Relationship, Drug
- Epitopes, T-Lymphocyte
- Genes, ras
- Humans
- Lung Neoplasms
- Mice
- Mice, Inbred BALB C
- Mutation
- Oncogene Protein p21(ras)
- Peptides
- Proto-Oncogene Mas