Article
Vaccination with mutant ras peptides and induction of T-cell responsiveness in pancreatic carcinoma patients carrying the corresponding RAS mutation.
Lancet (London, England) - 25 Nov 1995
Gjertsen M K, Bakka A, Breivik J, Saeterdal I, Solheim B G, Søreide O, Thorsby E, Gaudernack G
Abstract excerpt
Mutations in codon 12 of K-RAS are frequently found in pancreatic adenocarcinomas. T-cell responses specific for individual RAS mutations can be elicited in vitro by stimulation of peripheral blood mononuclear cells with synthetic peptides. Mutant ras peptides are therefore a candidate vaccine for specific immunotherapy in pancreatic carcinoma patients. When vaccinated with a synthetic ras peptide representing...
Topics
- Adenocarcinoma
- Antigen-Presenting Cells
- Humans
- Immunotherapy
- Leukapheresis
- Mutation
- Pancreatic Neoplasms
- T-Lymphocytes
- ras Proteins