p21-ras-peptide-specific T-cell responses in a patient with colorectal cancer. CD4+ and CD8+ T cells recognize a peptide corresponding to a common mutation (13Gly-->Asp).

doi:10.1002/ijc.2910560108

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Article

p21-ras-peptide-specific T-cell responses in a patient with colorectal cancer. CD4+ and CD8+ T cells recognize a peptide corresponding to a common mutation (13Gly-->Asp).

International journal of cancer - 2 Jan 1994

Fossum B, Gedde-Dahl T, Breivik J, Eriksen J A, Spurkland A, Thorsby E, Gaudernack G

Abstract excerpt

Peptides derived from mutated ras are immunogenic in mice and humans, and represent a group of specific tumor antigens that are potential targets for immunotherapy. T-cell responses against mutant p21 ras can be initiated in vitro by repeated stimulation of peripheral-blood mononuclear cells with...

Topics

Adenocarcinoma
Amino Acid Sequence
Aspartic Acid
CD4-Positive T-Lymphocytes
CD8 Antigens
Cells, Cultured
Colorectal Neoplasms
Female
Gene Amplification
Genes, ras
Glycine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Middle Aged

Molecular Sequence Data

Mutation

Peptides

Phenotype

Proto-Oncogene Proteins p21(ras)

Source

Open in PubMed

Identifiers

PMID: 7903287
DOI: 10.1002/ijc.2910560108

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7903287-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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