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Article

The ATPase motif in RAD51D is required for resistance to DNA interstrand crosslinking agents and interaction with RAD51C.

Mutagenesis - 1 Nov 2005

Gruver Aaron M, Miller Kristi A, Rajesh Changanamkandath, Smiraldo Phillip G, Kaliyaperumal Saravanan, Balder Rachel, Stiles Katie M, Albala Joanna S, Pittman Douglas L

Abstract excerpt

Homologous recombination (HR) is a mechanism for repairing DNA interstrand crosslinks and double-strand breaks. In mammals, HR requires the activities of the RAD51 family (RAD51, RAD51B, RAD51C, RAD51D, XRCC2, XRCC3 and DMC1), each of which contains conserved ATP binding sequences (Walker Motifs A and B). RAD51D is a DNA-stimulated ATPase that interacts directly with RAD51C and XRCC2. To test the hypothesis that...

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Source

Identifiers

PMID: 16236763
DOI: 10.1093/mutage/gei059

Genes

XRCC2
RAD51
DMC1
XRCC3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The ATPase motif in RAD51D is required for resistance to DNA interstrand crosslinking agents and interaction with RAD51C.PMID 16236763Read ↗

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