Article
The presence or absence of a retroviral long terminal repeat influences the genetic risk for type 1 diabetes conferred by human leukocyte antigen DQ haplotypes. Belgian Diabetes Registry.
The Journal of clinical endocrinology and metabolism - 1 Apr 1999
Donner H, Tönjes R R, Van der Auwera B, Siegmund T, Braun J, Weets I, Herwig J, Kurth R, Usadel K H, Badenhoop K
Abstract excerpt
Major genetic susceptibility to type 1 diabetes mellitus maps to the human leukocyte antigen (HLA) region on chromosome 6p. During evolution, endogenous retroviral long terminal repeats (LTR) have been integrated at several sites within this region. We analyzed the presence of a solitary HERV-K LTR in the HLA DQ region (DQ-LTR3) and its linkage to DRB1, DQA1, and DQB1 haplotypes derived from 246 German and...
Topics
- Diabetes Mellitus, Type 1
- Endogenous Retroviruses
- Female
- Genetic Predisposition to Disease
- HLA-DQ Antigens
- Haplotypes
- Heterozygote
- Humans
- Male
- Terminal Repeat Sequences