Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Vacuolating cytotoxin (vacA) alleles of Helicobacter pylori comprise two geographically widespread types, m1 and m2, and have evolved through limited recombination.

Current microbiology - 1 Oct 1999

Atherton J C, Sharp P M, Cover T L, Gonzalez-Valencia G, Peek R M, Thompson S A, Hawkey C J, Blaser M J

Abstract excerpt

Vacuolating cytotoxin (vacA) alleles of Helicobacter pylori vary, particularly in their mid region (which may be type m1 or m2) and their signal peptide coding region (type s1 or s2). We investigated nucleotide diversity among vacA alleles in strains from several locales in Asia, South America, and the USA. Phylogenetic analysis of vacA mid region sequences from 18 strains validated the division into two main...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacterial Proteins
Share to Cytotoxins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA, Bacterial

Share to Evolution, Molecular

Share to Helicobacter Infections

Share to Helicobacter pylori

Share to Phylogeny

Share to Recombination, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 10486057
DOI: 10.1007/s002849900447
PMCID: PMC2762107

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Vacuolating cytotoxin (vacA) alleles of Helicobacter pylori comprise two geographically widespread types, m1 and m2, and have evolved through limited recombination.PMID 10486057Read ↗

Simple and accurate PCR-based system for typing vacuolating cytotoxin alleles of Helicobacter pylori.Semantic proximity Read ↗

Geographical conservation of short inserts in the signal and middle regions of the Helicobacter pylori vacuolating cytotoxin gene.Semantic proximity Read ↗

Analysis and typing of the vacA gene from cagA-positive strains of Helicobacter pylori isolated in JapanSemantic proximity Read ↗

Expanding allelic diversity of Helicobacter pylori vacA.Semantic proximity Read ↗

Clinical and pathological importance of heterogeneity in vacA, the vacuolating cytotoxin gene of Helicobacter pylori.Semantic proximity Read ↗

Prevalence of vacuolating cytotoxin production and distribution of distinct vacA alleles in Helicobacter pylori from China.Semantic proximity Read ↗

Distinct variants of Helicobacter pylori cagA are associated with vacA subtypes.Semantic proximity Read ↗

New genotypes of Helicobacter Pylori VacA d-region identified from global strains.Semantic proximity Read ↗

Diversity of Helicobacter pylori vacA and cagA genes and relationship to VacA and CagA protein expression, cytotoxin production, and associated diseases.Semantic proximity Read ↗

Identification and analysis of a new vacA genotype variant of Helicobacter pylori in different patient groups in Germany.Semantic proximity Read ↗

DNA sequence analysis of South African Helicobacter pylori Vacuolating Cytotoxin Gene (vacA).Semantic proximity Read ↗

A new Helicobacter pylori vacuolating cytotoxin determinant, the intermediate region, is associated with gastric cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.