Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Distinct variants of Helicobacter pylori cagA are associated with vacA subtypes.

Journal of clinical microbiology - 1 Jul 1999

van Doorn L J, Figueiredo C, Sanna R, Blaser M J, Quint W G

Abstract excerpt

The diversity of the cytotoxin-associated gene (cagA) of Helicobacter pylori was analyzed in 45 isolates obtained from nine countries. We examined variation in the 5' end of the cagA open reading frame as determined by PCR and sequencing. Phylogenetic analysis revealed the existence of at least two distinct types of cagA. One variant (cagA1) was found exclusively in strains from Europe, the United States, and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Helicobacter Infections
Share to Antigens, Bacterial
Share to Bacterial Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Primers

Share to Helicobacter pylori

Share to Open Reading Frames

Share to Sequence Alignment

Share to Sequence Homology, Amino Acid

Source

Open in PubMed Open full text

Identifiers

PMID: 10364602
DOI: 10.1128/JCM.37.7.2306-2311.1999
PMCID: PMC85143

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Distinct variants of Helicobacter pylori cagA are associated with vacA subtypes.PMID 10364602Read ↗

Diversity of Helicobacter pylori vacA and cagA genes and relationship to VacA and CagA protein expression, cytotoxin production, and associated diseases.Semantic proximity Read ↗

Analysis and typing of the vacA gene from cagA-positive strains of Helicobacter pylori isolated in JapanSemantic proximity Read ↗

A global overview of the genetic and functional diversity in the Helicobacter pylori cag pathogenicity island.Semantic proximity Read ↗

Analysis of expression of CagA and VacA virulence factors in 43 strains of Helicobacter pylori reveals that clinical isolates can be divided into two major types and that CagA is not necessary for expression of the vacuolating cytotoxinSemantic proximity Read ↗

Genetic diversity of Helicobacter pylori type IV secretion system cagI and cagN genes and their association with clinical diseases.Semantic proximity Read ↗

Variations in Helicobacter pylori cytotoxin-associated genes and their influence in progression to gastric cancer: implications for prevention.Semantic proximity Read ↗

Expanding allelic diversity of Helicobacter pylori vacA.Semantic proximity Read ↗

Conservation of the cag pathogenicity island is associated with vacA alleles and gastroduodenal disease in South African Helicobacter pylori isolates.Semantic proximity Read ↗

Geographic differences and the role of cagA gene in gastroduodenal diseases associated with Helicobacter pylori infection.Semantic proximity Read ↗

cagA genotype and variants in Chinese Helicobacter pylori strains and relationship to gastroduodenal diseases.Semantic proximity Read ↗

Conservation of the cag pathogenicity island of Helicobacter pylori: associations with vacuolating cytotoxin allele and IS605 diversity.Semantic proximity Read ↗

Vacuolating cytotoxin (vacA) alleles of Helicobacter pylori comprise two geographically widespread types, m1 and m2, and have evolved through limited recombination.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.