Novel Escherichia coli mutant, dnaR, thermosensitive in initiation of chromosome replication.

Abstract excerpt

A newly isolated Escherichia coli mutant thermosensitive in DNA synthesis had an allele named dnaR130, which was located at 26.3 minutes on the genetic map. The mutant was defective in initiation of chromosome replication but not in propagation at a high temperature. This mutant was capable of growing in the absence of the rnh function at the high temperature by means of a dnaA-independent replication mechanism....

Topics

• Bacterial Proteins
• Chromosome Mapping
• Chromosomes, Bacterial
• DNA Replication
• DNA-Binding Proteins
• Escherichia coli
• Genes, Bacterial
• Hot Temperature
• Mutation
• Plasmids