Article
Autosome search for schizophrenia susceptibility genes in multiply affected families.
Molecular psychiatry - 1 Jul 1999
Rees M I, Fenton I, Williams N M, Holmans P, Norton N, Cardno A, Asherson P, Spurlock G, Roberts E, Parfitt E, Mant R, Vallada H, Dawson E, Li M W, Collier D A, Powell J F, Nanko S, Gill M, McGuffin P, Owen M J
Abstract excerpt
We have analysed 298 polymorphic markers in 13 families multiply affected with schizophrenia and related disorders using a combination of radiolabelled and fluorescent-based methodologies. The markers were distributed throughout the autosomes at an average spacing of 12.8 cM. The data were analysed with two-point linkage analysis (MLINK) and heterogeneity testing (HOMOG). Several genetic models were used ranging...
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