Article
Suggestive evidence for a schizophrenia susceptibility locus on chromosome 6q and a confirmation in an independent series of pedigrees.
Genomics - 1 Jul 1997
Cao Q, Martinez M, Zhang J, Sanders A R, Badner J A, Cravchik A, Markey C J, Beshah E, Guroff J J, Maxwell M E, Kazuba D M, Whiten R, Goldin L R, Gershon E S, Gejman P V
Abstract excerpt
We have investigated whether there is a locus on chromosome 6 that confers an increased susceptibility to schizophrenia using a two-stage approach and nonparametric linkage analysis. Allele sharing identical by descent (IBD) and multipoint maximum likelihood score (MLS) statistics were employed....
Topics
- Alleles
- Chromosome Mapping
- Chromosomes, Human, Pair 6
- Female
- Genetic Linkage
- Genetic Markers
- Humans
- Likelihood Functions
- Male
- Pedigree
- Schizophrenia