Article
Genome-wide scans of three independent sets of 90 Irish multiplex schizophrenia families and follow-up of selected regions in all families provides evidence for multiple susceptibility genes.
Molecular psychiatry - 1 Jan 2002
Straub R E, MacLean C J, Ma Y, Webb B T, Myakishev M V, Harris-Kerr C, Wormley B, Sadek H, Kadambi B, O'Neill F A, Walsh D, Kendler K S
Abstract excerpt
From our linkage study of Irish families with a high density of schizophrenia, we have previously reported evidence for susceptibility genes in regions 5q21-31, 6p24-21, 8p22-21, and 10p15-p11. In this report, we describe the cumulative results from independent genome scans of three a priori random subsets of 90 families each, and from multipoint analysis of all 270 families in ten regions. Of these ten regions,...
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