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Article

Interleukin 22 is a candidate gene for Tmevp3, a locus controlling Theiler's virus-induced neurological diseases.

Genetics - 1 Jul 2007

Levillayer F, Mas M, Levi-Acobas F, Brahic M, Bureau J F

Abstract excerpt

After intracerebral inoculation, Theiler's virus induces in its natural host, the mouse, an acute encephalomyelitis followed, in susceptible animals, by chronic inflammation and primary demyelination. Susceptibility to demyelination among strains of laboratory mice is explained by the capacity of the immune system to control viral load during persistence. Also, differences of susceptibility to viral load between...

Topics

Animals
Demyelinating Diseases
Encephalomyelitis
Genetic Predisposition to Disease
Interleukins
Mice
Nervous System Diseases
Survival Rate
Theilovirus
Interleukin-22

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17483407
DOI: 10.1534/genetics.107.073536
PMCID: PMC1931528

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