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Article

Functional consequence of positive selection revealed through rational mutagenesis of human myeloperoxidase.

Molecular biology and evolution - 1 Aug 2012

Loughran Noeleen B, Hinde Sara, McCormick-Hill Sally, Leidal Kevin G, Bloomberg Sarah, Loughran Sinéad T, O'Connor Brendan, O'Fágáin Ciarán, Nauseef William M, O'Connell Mary J

Abstract excerpt

Myeloperoxidase (MPO) is a member of the mammalian heme peroxidase (MHP) multigene family. Whereas all MHPs oxidize specific halides to generate the corresponding hypohalous acid, MPO is unique in its capacity to oxidize chloride at physiologic pH to produce hypochlorous acid (HOCl), a potent microbicide that contributes to neutrophil-mediated host defense against infection. We have previously resolved the...

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Identifiers

PMID: 22355012
DOI: 10.1093/molbev/mss073
PMCID: PMC3408071

Genes

MPO

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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