Pattern of inheritance in hereditary myeloperoxidase deficiency associated with the R569W missense mutation.

doi:10.1002/jlb.63.2.264

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Article

Pattern of inheritance in hereditary myeloperoxidase deficiency associated with the R569W missense mutation.

Journal of leukocyte biology - 1 Feb 1998

Nauseef W M, Cogley M, Bock S, Petrides P E

Abstract excerpt

Myeloperoxidase (MPO) is an essential component of the oxygen-dependent microbicidal system of neutrophils and monocytes. Hereditary deficiency of MPO occurs in 1 in 2,000 to 4,000 individuals in the general population and has been generally considered an autosomal recessive trait. Previous studi...

Topics

Female
Genes, Recessive
Humans
Male
Neutrophils
Pedigree
Peroxidase
Phenotype
Point Mutation

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