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Article

Screening of the human tumor necrosis factor-alpha (TNF-alpha) gene promoter polymorphisms by PCR-DGGE analysis.

Mutation research - 1 Aug 1999

Patiño-García A, Sotillo-Piñeiro E, Modesto C, Sierrasesúmaga L

Abstract excerpt

We have designed a new PCR-DGGE technique that enables detection of base changes in the TNF-alpha gene promoter. Screening of 130 samples from Spanish children has shown that this technique accurately detects the altered band patterns induced by the presence of the polymorphisms at positions -376, -308, -238 and -163 of the promoter sequence. Although further analysis are needed to fully characterise the...

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Share to Electrophoresis, Polyacrylamide Gel
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Polymerase Chain Reaction

Share to Polymorphism, Restriction Fragment Length

Share to Promoter Regions, Genetic

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Source

Identifiers

PMID: 10479729
DOI: 10.1016/s1383-5726(99)00004-7

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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