Article
TNF-alpha promoter gene polymorphisms in Spanish children with persistent oligoarticular and systemic-onset juvenile idiopathic arthritis.
Scandinavian journal of rheumatology - 1 Jan 2000
Modesto C, Patiño-García A, Sotillo-Piñeiro E, Merino J, García-Consuegra J, Merino R, Rua M J, Sierrasesúmaga L, Arnal C
Abstract excerpt
OBJECTIVE: To explore the possible association/s of the first reported tumour necrosis factor (TNF-alphaTNF-) alpha promoter gene polymorphisms -308, -238, -376 and -163 (G-->A) with systemic (SoJIA) and oligoarticular subtypes of juvenile idiopathic arthritis (JIA); and to test the association between these polymorphisms and the class I/class II HLA alleles in our population. METHODS: The patient group comprised...
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