Article
Genetic polymorphisms of tumour necrosis factor alpha (TNF-α) promoter gene and response to TNF-α inhibitors in Spanish patients with inflammatory bowel disease.
International journal of immunogenetics - 1 Feb 2014
López-Hernández R, Valdés M, Campillo J A, Martínez-Garcia P, Salama H, Salgado G, Boix F, Moya-Quiles M R, Minguela A, Sánchez-Torres A, Miras M, Garcia A, Carballo F, Álvarez-López M R, Muro M
Abstract excerpt
Tumour necrosis factor alpha (TNF-α) has an important role in inflammatory response. Alterations in the regulation of TNF-α have been implicated in a variety of inflammatory disorders, including Inflammatory bowel disease (IBD). Indeed, a common treatment for IBD is the use of TNF-α inhibitors. Polymorphisms in the TNF-α promoter region are known to affect the level of gene expression. Our aim was to investigate...
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