Article
The mutagenically separated polymerase chain reaction is a rapid and reliable method for genotyping of the tumour necrosis factor-alpha promoter polymorphism (-308 G/A).
Clinica chimica acta; international journal of clinical chemistry - 1 Jun 2002
Schlüter Bernhard, Erren Michael, Schotte Heiko, Junker Ralf, Rust Stephan, Assmann Gerd
Abstract excerpt
BACKGROUND: The tumour necrosis factor-alpha (TNF alpha) promoter polymorphism (-308 G/A) has been shown to be associated with the susceptibility to and/or the severity of diverse diseases such as infections, autoimmunity, and malignancies. We developed a genotyping technique based on the mutagenically separated polymerase chain reaction (MS-PCR) which may be useful in the clinical risk assessment. METHODS:...
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