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Article

Rescue of cerebellar granule cells from death in weaver NR1 double mutants.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Sept 1999

Jensen P, Surmeier D J, Goldowitz D

Abstract excerpt

The weaver mutation results in the extensive death of midline cerebellar granule cells. The mutation consists of a single base pair substitution of the gene encoding the G-protein-activated inwardly rectifying potassium channel protein, GIRK2. The functional consequences of this mutation are still in dispute. In this study we demonstrate the in vivo and in vitro rescue of weaver granule cells when NR1 NMDA...

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Identifiers

PMID: 10479699
PMCID: PMC6782480

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Rescue of cerebellar granule cells from death in weaver NR1 double mutants.PMID 10479699Read ↗

The weaver mutation of GIRK2 results in a loss of inwardly rectifying K+ current in cerebellar granule cells.Semantic proximity Read ↗

Cell death in weaver mouse cerebellum.Semantic proximity Read ↗

Inhibition of caspases protects cerebellar granule cells of the weaver mouse from apoptosis and improves behavioral phenotype.Semantic proximity Read ↗

The inwardly rectifying K(+) channel subunit GIRK1 rescues the GIRK2 weaver phenotype.Semantic proximity Read ↗

Normal cerebellar development but susceptibility to seizures in mice lacking G protein-coupled, inwardly rectifying K+ channel GIRK2.Semantic proximity Read ↗

Heteromeric channel formation and Ca(2+)-free media reduce the toxic effect of the weaver Kir 3.2 allele.Semantic proximity Read ↗

Girk2 expression in the ventral midbrain, cerebellum, and olfactory bulb and its relationship to the murine mutation weaver.Semantic proximity Read ↗

Transgenic rescue for characterizing orphan receptors: a review of delta2 glutamate receptor.Semantic proximity Read ↗

Elevated intracellular calcium levels in cerebellar granule neurons of weaver mice.Semantic proximity Read ↗

Assessment of a mutation in the H5 domain of Girk2 as a candidate for the weaver mutation.Semantic proximity Read ↗

Death and survival of heterozygous Lurcher Purkinje cells in vitro.Semantic proximity Read ↗

Cell death during development of testis and cerebellum in the mutant mouse weaver.Semantic proximity Read ↗

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