Article
The weaver mutation of GIRK2 results in a loss of inwardly rectifying K+ current in cerebellar granule cells.
Proceedings of the National Academy of Sciences of the United States of America - 1 Oct 1996
Surmeier D J, Mermelstein P G, Goldowitz D
Abstract excerpt
The weaver mutation in mice results in a severe ataxia that is attributable to the degeneration of cerebellar granule cells and dopaminergic neurons in the substantia nigra. Recent genetic studies indicate that the GIRK2 gene is altered in weaver. This gene codes for a G-protein-activated, inward...
Topics
- Animals
- Cerebellum
- G Protein-Coupled Inwardly-Rectifying Potassium Channels
- GTP-Binding Proteins
- Mice
- Mice, Neurologic Mutants
- Mutation
- Parkinson Disease
- Potassium
- Potassium Channels
- Potassium Channels, Inwardly Rectifying