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Article

The weaver mutation of GIRK2 results in a loss of inwardly rectifying K+ current in cerebellar granule cells.

Proceedings of the National Academy of Sciences of the United States of America - 1 Oct 1996

Surmeier D J, Mermelstein P G, Goldowitz D

Abstract excerpt

The weaver mutation in mice results in a severe ataxia that is attributable to the degeneration of cerebellar granule cells and dopaminergic neurons in the substantia nigra. Recent genetic studies indicate that the GIRK2 gene is altered in weaver. This gene codes for a G-protein-activated, inwardly rectifying K+ channel protein (8). The mutation results in a single amino acid substitution (glycine-->serine) in...

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Identifiers

PMID: 8855331
DOI: 10.1073/pnas.93.20.11191
PMCID: PMC38306

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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The weaver mutation of GIRK2 results in a loss of inwardly rectifying K+ current in cerebellar granule cells.PMID 8855331Read ↗

Cell death in weaver mouse cerebellum.Semantic proximity Read ↗

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The weaver mouse gain-of-function phenotype of dopaminergic midbrain neurons is determined by coactivation of wvGirk2 and K-ATP channels.Semantic proximity Read ↗

Normal cerebellar development but susceptibility to seizures in mice lacking G protein-coupled, inwardly rectifying K+ channel GIRK2.Semantic proximity Read ↗

Inhibition of caspases protects cerebellar granule cells of the weaver mouse from apoptosis and improves behavioral phenotype.Semantic proximity Read ↗

The inwardly rectifying K(+) channel subunit GIRK1 rescues the GIRK2 weaver phenotype.Semantic proximity Read ↗

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Nigrostriatal Dopaminergic Neurodegeneration in theWeaverMouse Is Mediated via Neuroinflammation and Alleviated by Minocycline AdministrationSemantic proximity Read ↗

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