Article
Assessment of a mutation in the H5 domain of Girk2 as a candidate for the weaver mutation.
Genome research - 1 Dec 1995
Mjaatvedt A E, Cabin D E, Cole S E, Long L J, Breitwieser G E, Reeves R H
Abstract excerpt
A mutation in the GIRK2 inwardly rectifying K+ channel was mapped recently to the region of mouse chromosome 16 containing the wv gene and shown to occur in mutant but not in wild-type mice. We demonstrate tight linkage of the Girk2 mutation to the wv phenotype and refine the localization of the...
Topics
- Animals
- Base Sequence
- Cells, Cultured
- Cerebellum
- Chromosome Mapping
- Chromosomes, Artificial, Yeast
- Crosses, Genetic
- DNA Primers
- Female
- G Protein-Coupled Inwardly-Rectifying Potassium Channels
- Genetic Linkage
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Neurologic Mutants
- Molecular Sequence Data
- Mutation
- Phenotype