Girk2 expression in the ventral midbrain, cerebellum, and olfactory bulb and its relationship to the murine mutation weaver.

Abstract excerpt

The mouse mutant weaver exhibits developmental deficits and cell death in several neuronal classes. weaver is almost certainly a mutation in the potassium channel, Girk2. In some vulnerable neurons, including those in the midbrain, it is not known whether weaver expression is the primary defect, or whether deficits are secondary to weaver expression elsewhere. In wild-type mice, our results point to subsets of...

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