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Article

Inhibition of caspases protects cerebellar granule cells of the weaver mouse from apoptosis and improves behavioral phenotype.

The Journal of biological chemistry - 15 Nov 2002

Peng Jun, Wu Zhijin, Wu Yongqin, Hsu Mike, Stevenson Fang Feng, Boonplueang Rapee, Roffler-Tarlov Suzanne K, Andersen Julie K

Abstract excerpt

The homozygous mouse mutant weaver exhibits a massive loss of cerebellar granule neurons postnatally. The death of these cells is associated with a single amino acid mutation in the G protein-activated inwardly rectifying potassium channel, Girk2. Evidence suggests that both the mutated Girk2 channel and the calcium channel-associated N-methyl-d-aspartate receptor play important roles in the apoptotic death of...

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Identifiers

PMID: 12221097
DOI: 10.1074/jbc.M207407200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inhibition of caspases protects cerebellar granule cells of the weaver mouse from apoptosis and improves behavioral phenotype.PMID 12221097Read ↗

Cell death in weaver mouse cerebellum.Semantic proximity Read ↗

The weaver mutation of GIRK2 results in a loss of inwardly rectifying K+ current in cerebellar granule cells.Semantic proximity Read ↗

Rescue of cerebellar granule cells from death in weaver NR1 double mutants.Semantic proximity Read ↗

Elevated intracellular calcium levels in cerebellar granule neurons of weaver mice.Semantic proximity Read ↗

Cell death during development of testis and cerebellum in the mutant mouse weaver.Semantic proximity Read ↗

Nigrostriatal Dopaminergic Neurodegeneration in theWeaverMouse Is Mediated via Neuroinflammation and Alleviated by Minocycline AdministrationSemantic proximity Read ↗

Normal cerebellar development but susceptibility to seizures in mice lacking G protein-coupled, inwardly rectifying K+ channel GIRK2.Semantic proximity Read ↗

Inhibition of insulin-like growth factor I activity contributes to the premature apoptosis of cerebellar granule neuron in weaver mutant mice: in vitro analysis.Semantic proximity Read ↗

Girk2 expression in the ventral midbrain, cerebellum, and olfactory bulb and its relationship to the murine mutation weaver.Semantic proximity Read ↗

A cell cycle alteration precedes apoptosis of granule cell precursors in the weaver mouse cerebellum.Semantic proximity Read ↗

Fluoro-jade identification of cerebellar granule cell and purkinje cell death in the alpha1A calcium ion channel mutant mouse, leaner.Semantic proximity Read ↗

Defects in regulation of apoptosis in caspase-2-deficient mice.Semantic proximity Read ↗

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