Article
Elevated intracellular calcium levels in cerebellar granule neurons of weaver mice.
Neuroreport - 26 Oct 1998
Womack M, Thompson K, Fanselow E, Augustine G J, Peterson A
Abstract excerpt
Weaver mice carry a mutation in the pore domain of the Girk2 (Kcnj6) gene. The mutation causes GIRK2 containing channels to lose ion selectivity and to become constitutively active. It is not known how this alteration in ion channel activity causes in cerebellar granule cells the defects in neuri...
Topics
- Animals
- Brain Chemistry
- Calcium
- Cerebellum
- Fluorescent Dyes
- Fura-2
- G Protein-Coupled Inwardly-Rectifying Potassium Channels
- Mice
- Mice, Neurologic Mutants
- Mutation
- Nerve Degeneration
- Neurons
- Phenotype
- Potassium Channels
- Potassium Channels, Inwardly Rectifying