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Article

The Drosophila E74 gene is required for metamorphosis and plays a role in the polytene chromosome puffing response to ecdysone.

Development (Cambridge, England) - 1 May 1995

Fletcher J C, Burtis K C, Hogness D S, Thummel C S

Abstract excerpt

The steroid hormone ecdysone initiates Drosophila metamorphosis by reprogramming gene expression during late larval and prepupal development. The ecdysone-inducible gene E74, a member of the ets proto-oncogene family, has been proposed to play a key role in this process. E74 is encoded within the 74EF early puff and consists of two overlapping transcription units, E74A and E74B. To assess the function(s) of E74...

Topics

Animals
Base Sequence
Chromatin
Chromosomes
DNA Primers
DNA-Binding Proteins
Drosophila
Drosophila Proteins
Ecdysone
Genes, Insect
Metamorphosis, Biological

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Phenotype

Salivary Glands

Transcription Factors

Source

Identifiers

PMID: 7789275
DOI: 10.1242/dev.121.5.1455

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7789275-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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The Drosophila E74 gene is required for metamorphosis and plays a role in the polytene chromosome puffing response to ecdysone.PMID 7789275Read ↗

The Drosophila E74 gene is required for the proper stage- and tissue-specific transcription of ecdysone-regulated genes at the onset of metamorphosis.Semantic proximity Read ↗

The 82F late puff contains the L82 gene, an essential member of a novel gene family.Semantic proximity Read ↗

The E23 early gene of Drosophila encodes an ecdysone-inducible ATP-binding cassette transporter capable of repressing ecdysone-mediated gene activation.Semantic proximity Read ↗

The L63 gene is necessary for the ecdysone-induced 63E late puff and encodes CDK proteins required for Drosophila development.Semantic proximity Read ↗

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Broad-Complex, E74, and E75 early genes control DNA puff BhC4-1 expression in prepupal salivary glands.Semantic proximity Read ↗

The ecdysone-inducible Broad-complex and E74 early genes interact to regulate target gene transcription and Drosophila metamorphosis.Semantic proximity Read ↗

Loss of the ecdysteroid-inducible E75A orphan nuclear receptor uncouples molting from metamorphosis in Drosophila.Semantic proximity Read ↗

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The Drosophila Broad-Complex plays a key role in controlling ecdysone-regulated gene expression at the onset of metamorphosis.Semantic proximity Read ↗

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