Article
Transforming growth factor-beta1 promoter polymorphism C-509T is associated with asthma.
American journal of respiratory and critical care medicine - 15 Jan 2004
Silverman Eric S, Palmer Lyle J, Subramaniam Venkat, Hallock Arlene, Mathew Sheeba, Vallone Joseph, Faffe Debora S, Shikanai Toshiki, Raby Benjamin A, Weiss Scott T, Shore Stephanie A
Abstract excerpt
Transforming growth factor-beta1 (TGF-beta1) is increased in the lungs of individuals with asthma and may modulate airway inflammation and remodeling. Some genetic studies have found that a C-to-T single-nucleotide polymorphism (C-509T) in the TGF-beta1 gene promoter may be associated with altered gene expression and asthma phenotype. To build on these data, we performed a case-control association study at this...
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