Article
Association between the IL-4 promoter polymorphisms and asthma or severity of hyperresponsiveness in Taiwanese.
Respirology (Carlton, Vic.) - 1 Jan 2007
Chiang Chi-Huei, Tang Ying-Chuan, Lin Ming-Wei, Chung Ming-Yi
Abstract excerpt
BACKGROUND AND OBJECTIVES: Recent family-based studies have revealed a linkage between human chromosome 5q31 and asthma, elevated serum IgE levels and airway hyperresponsiveness (AHR). Among the candidate genes in this region is the gene encoding IL-4. This gene could be a candidate gene for asthma. The aim of this prospective case-control study was to assess the frequency of polymorphisms in the IL-4 gene...
Topics
- Adult
- Asthma
- Case-Control Studies
- DNA
- Female
- Follow-Up Studies
- Gene Frequency
- Genotype
- Humans
- Incidence
- Interleukin-4
- Male
- Middle Aged
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Promoter Regions, Genetic
- Prospective Studies
- Severity of Illness Index
