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Article

A genome-wide association study of pulmonary function measures in the Framingham Heart Study.

PLoS genetics - 1 Mar 2009

Wilk Jemma B, Chen Ting-Hsu, Gottlieb Daniel J, Walter Robert E, Nagle Michael W, Brandler Brian J, Myers Richard H, Borecki Ingrid B, Silverman Edwin K, Weiss Scott T, O'Connor George T

Abstract excerpt

The ratio of forced expiratory volume in one second to forced vital capacity (FEV(1)/FVC) is a measure used to diagnose airflow obstruction and is highly heritable. We performed a genome-wide association study in 7,691 Framingham Heart Study participants to identify single-nucleotide polymorphisms (SNPs) associated with the FEV(1)/FVC ratio, analyzed as a percent of the predicted value. Identified SNPs were...

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Share to Chromosomes, Human, Pair 4
Share to Forced Expiratory Volume

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome, Human

Share to Membrane Glycoproteins

Share to Pulmonary Disease, Chronic Obstructive

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Source

Open in PubMed Open full text

Identifiers

PMID: 19300500
DOI: 10.1371/journal.pgen.1000429
PMCID: PMC2652834

Genes

FEV
HHIP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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