Article
Association of asthma with a functional promoter polymorphism in the IL16 gene.
The Journal of allergy and clinical immunology - 1 Jan 2006
Burkart Kristin M, Barton Sheila J, Holloway John W, Yang Ian A, Cakebread Julie A, Cruikshank William, Little Frederic, Jin Xiaoyi, Farrer Lindsay A, Clough Joanne B, Keith Tim P, Holgate Stephen, Center David M, O'Connor George T
Abstract excerpt
BACKGROUND: IL-16, a multifunctional cytokine with increased expression in the airways of asthmatic subjects, inhibits allergic airway inflammation in animal models. A T-->C single nucleotide polymorphism (SNP) at the -295 position in the promoter region of the IL16 gene has been described. OBJECTIVE: We sought to examine the functional significance of this promoter SNP and its relationship to asthma. METHODS: We...
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