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Article

A Functional Polymorphism in IL-18 Is Associated with Severity of Bronchial Asthma

10 Sept 2009

Abstract excerpt

RATIONALE: IL-18 is a unique cytokine that enhances innate immunity and both Th1- and Th2-driven immune responses. Recent murine and human genetic studies have shown its role in the pathogenesis of asthma. OBJECTIVES: We conducted an association study in a Japanese population to discover variants of IL-18 that might have an effect on asthma susceptibility and/or progression and conducted functional analyses of...

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PMID: 19745201
DOI: 10.1164/rccm.200905-0652oc

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