Article
Involvement of Ral GTPase in v-Src-induced phospholipase D activation.
Nature - 23 Nov 1995
Jiang H, Luo J Q, Urano T, Frankel P, Lu Z, Foster D A, Feig L A
Abstract excerpt
An early response to the tyrosine kinase activity of v-Src is an increase in phospholipase D (PLD) activity, which leads to the generation of biologically active lipid second messengers, including phosphatidic acid, lysophosphatidic acid and diacylglycerol. We have recently demonstrated that v-Src-induced PLD activity is mediated by Ras, although Ras involvement was indirect, requiring a cytosolic factor for PLD...
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