Article
Involvement of Ral GTPase in v-Src-induced phospholipase D activation.
Nature - 23 Nov 1995
Jiang H, Luo J Q, Urano T, Frankel P, Lu Z, Foster D A, Feig L A
Abstract excerpt
An early response to the tyrosine kinase activity of v-Src is an increase in phospholipase D (PLD) activity, which leads to the generation of biologically active lipid second messengers, including phosphatidic acid, lysophosphatidic acid and diacylglycerol. We have recently demonstrated that v-Sr...
Topics
- 3T3 Cells
- Animals
- Cell Line, Transformed
- Enzyme Activation
- Enzymes, Immobilized
- GTP Phosphohydrolases
- GTP-Binding Proteins
- Mice
- Mice, Inbred BALB C
- Mutation
- Oncogene Protein pp60(v-src)
- Phospholipase D
- Recombinant Fusion Proteins
- ral GTP-Binding Proteins
- ras Proteins