Urokinase-type plasminogen activator receptor (uPAR) expression enhances invasion and metastasis in RAS mutated tumors.

doi:10.1038/s41598-017-10062-1

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Article

Urokinase-type plasminogen activator receptor (uPAR) expression enhances invasion and metastasis in RAS mutated tumors.

Scientific reports - 24 Aug 2017

Mauro Concetta Di, Pesapane Ada, Formisano Luigi, Rosa Roberta, D'Amato Valentina, Ciciola Paola, Servetto Alberto, Marciano Roberta, Orsini Roberta Clara, Monteleone Francesca, Zambrano Nicola, Fontanini Gabriella, Servadio Adele, Pignataro Giuseppe, Grumetto Lucia, Lavecchia Antonio, Bruzzese Dario, Iaccarino Antonino, Troncone Giancarlo, Veneziani Bianca Maria, Montuori Nunzia, Placido Sabino De, Bianco Roberto

Abstract excerpt

The urokinase-type plasminogen activator receptor (uPAR) is a GPI-anchored cell membrane receptor that focuses urokinase (uPA) proteolytic activity on the cell surface. Its expression is increased in many human cancers, including non-small cell lung cancer (NSCLC) and colorectal cancer (CRC), and correlates with a poor prognosis and early invasion and metastasis. uPAR is able to control, through a cross-talk with...

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PMID: 28839232
DOI: 10.1038/s41598-017-10062-1
PMCID: PMC5571185

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