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Article

Phospholipase D and RalA cooperate with the epidermal growth factor receptor to transform 3Y1 rat fibroblasts.

Molecular and cellular biology - 1 Jan 2000

Lu Z, Hornia A, Joseph T, Sukezane T, Frankel P, Zhong M, Bychenok S, Xu L, Feig L A, Foster D A

Abstract excerpt

3Y1 rat fibroblasts overexpressing the epidermal growth factor (EGF) receptor (EGFR cells) become transformed when treated with EGF. A common response to oncogenic and mitogenic stimuli is elevated phospholipase D (PLD) activity. RalA, a small GTPase that functions as a downstream effector molecule of Ras, exists in a complex with PLD1. In the EGFR cells, EGF induced a Ras-dependent activation of RalA. The...

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Source

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Identifiers

PMID: 10611224
DOI: 10.1128/MCB.20.2.462-467.2000
PMCID: PMC85102

Genes

EGF
EGFR
PLD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Phospholipase D and RalA cooperate with the epidermal growth factor receptor to transform 3Y1 rat fibroblasts.PMID 10611224Read ↗

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Involvement of Ral GTPase in v-Src-induced phospholipase D activation.Semantic proximity Read ↗

The direct interaction of phospholipase C-gamma 1 with phospholipase D2 is important for epidermal growth factor signaling.Semantic proximity Read ↗

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Activation of RalA is critical for Ras-induced tumorigenesis of human cellsSemantic proximity Read ↗

Phospholipase D provides a survival signal in human cancer cells with activated H-Ras or K-RasSemantic proximity Read ↗

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