Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rac1 and Cdc42 are regulators of HRasV12-transformation and angiogenic factors in human fibroblasts.

BMC cancer - 12 Jan 2010

Appledorn Daniel M, Dao Kim-Hien T, O'Reilly Sandra, Maher Veronica M, McCormick J Justin

Abstract excerpt

BACKGROUND: The activities of Rac1 and Cdc42 are essential for HRas-induced transformation of rodent fibroblasts. What is more, expression of constitutively activated mutants of Rac1 and/or Cdc42 is sufficient for their malignant transformation. The role for these two Rho GTPases in HRas-mediated transformation of human fibroblasts has not been studied. Here we evaluated the contribution of Rac1 and Cdc42 to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to cdc42 GTP-Binding Protein
Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neovascularization, Pathologic

Share to rac1 GTP-Binding Protein

Share to ras Proteins

Share to rho GTP-Binding Proteins

Share to Tetracycline

Share to Vascular Endothelial Growth Factor A

Source

Open in PubMed Open full text

Identifiers

PMID: 20067638
DOI: 10.1186/1471-2407-10-13
PMCID: PMC2826294

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rac1 and Cdc42 are regulators of HRasV12-transformation and angiogenic factors in human fibroblasts.PMID 20067638Read ↗

Mammary epithelial cell transformation: insights from cell culture and mouse modelsSemantic proximity Read ↗

Activation of RalA is critical for Ras-induced tumorigenesis of human cellsSemantic proximity Read ↗

Targeting Rac and Cdc42 GTPases in CancerSemantic proximity Read ↗

Autocrine activation of an osteopontin-CD44-Rac pathway enhances invasion and transformation by H-RasV12.Semantic proximity Read ↗

Selectivity of Guanine Nucleotide Exchange Factor-mediated Cdc42 activation in primary human endothelial cellsSemantic proximity Read ↗

Oncogenic Transformation of Human Mammary Epithelial Cells by Autocrine Human Growth HormoneSemantic proximity Read ↗

Transforming mutations of RAC guanosine triphosphatases in human cancers.Semantic proximity Read ↗

Review of: Oncogenic transformation of human mammary epithelial cells by autocrine human growth hormoneSemantic proximity Read ↗

H-Ras-specific activation of Rac-MKK3/6-p38 pathway: its critical role in invasion and migration of breast epithelial cells.Semantic proximity Read ↗

The role of Rac1 in maintaining malignant phenotype of mouse skin tumor cells.Semantic proximity Read ↗

RASless MEFs as a Tool to Study RAS-Dependent and RAS-Independent Functions.Semantic proximity Read ↗

Rac1 and extracellularly regulated kinase activation are sufficient for E1A-dependent cooperative transformation of primary epithelial cells, but progression can only be modulated by E1A or Rac1.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.