Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evidence that transcription factor IIB is required for a post-assembly step in transcription initiation.

The Journal of biological chemistry - 3 Sept 1999

Cho E J, Buratowski S

Abstract excerpt

Mutation of glutamate 62 to lysine in yeast transcription factor (TF) IIB (Sua7) causes a cold-sensitive phenotype. This mutant also leads to preferential transcription of downstream start sites on some promoters in vivo. To explore the molecular nature of these phenotypes, the TFIIB E62K mutant was characterized in vitro. The mutant interacts with TATA-binding protein normally. In three different assays, the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Mutation
Share to Saccharomyces cerevisiae
Share to TATA Box

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Transcription Factor TFIIB

Share to Transcription Factors

Share to Transcription, Genetic

Share to Transcriptional Activation

Source

Identifiers

PMID: 10464320
DOI: 10.1074/jbc.274.36.25807

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evidence that transcription factor IIB is required for a post-assembly step in transcription initiation.PMID 10464320Read ↗

Functional interaction between TFIIB and the Rpb2 subunit of RNA polymerase II: implications for the mechanism of transcription initiation.Semantic proximity Read ↗

Characterization of sua7 mutations defines a domain of TFIIB involved in transcription start site selection in yeast.Semantic proximity Read ↗

The role of TFIIB-RNA polymerase II interaction in start site selection in yeast cells.Semantic proximity Read ↗

Assembly of transcription factor IIB at a promoter in vivo requires contact with RNA polymerase II.Semantic proximity Read ↗

Minimal promoter systems reveal the importance of conserved residues in the B-finger of human transcription factor IIB.Semantic proximity Read ↗

Functional interaction between Ssu72 and the Rpb2 subunit of RNA polymerase II in Saccharomyces cerevisiae.Semantic proximity Read ↗

Mutational analysis of yeast TFIIB. A functional relationship between Ssu72 and Sub1/Tsp1 defined by allele-specific interactions with TFIIB.Semantic proximity Read ↗

Synthetic enhancement of a TFIIB defect by a mutation in SSU72, an essential yeast gene encoding a novel protein that affects transcription start site selection in vivo.Semantic proximity Read ↗

Important role in transcription start site selection for the RNA polymerase II-TFIIE-TFIIH interface in Saccharomyces cerevisiae.Semantic proximity Read ↗

Position of the general transcription factor TFIIF within the RNA polymerase II transcription preinitiation complex.Semantic proximity Read ↗

Association of transcription factor IIA with TATA binding protein is required for transcriptional activation of a subset of promoters and cell cycle progression in Saccharomyces cerevisiae.Semantic proximity Read ↗

High-resolution protein-DNA contacts for the yeast RNA polymerase II general transcription machinery.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.