Article
Culture-independent prediction of isoniazid resistance in Mycobacterium tuberculosis by katG gene analysis directly from sputum samples.
Molecular diagnosis : a journal devoted to the understanding of human disease through the clinical application of molecular biology - 1 Jun 1999
Rinder H, Feldmann K, Tortoli E, Grosset J, Casal M, Richter E, Rifai M, Jarlier V, Vaquero M, Rüsch-Gerdes S, Cambau E, Gutierrez J, Löscher T
Abstract excerpt
BACKGROUND: The molecular prediction of isoniazid (INH) resistance in Mycobacterium tuberculosis is hampered by the need for specialized equipment, expertise, high costs, a limited range of detectable mutations, or several of these factors. The rationale for the study was to find a practical alternative and to demonstrate generally valid problems. METHODS AND RESULTS: DNA extracted from decontaminated sputum...
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