Article
Isoniazid resistance levels of Mycobacterium tuberculosis can largely be predicted by high-confidence resistance-conferring mutations.
Scientific reports - 19 Feb 2018
Lempens Pauline, Meehan Conor J, Vandelannoote Koen, Fissette Kristina, de Rijk Pim, Van Deun Armand, Rigouts Leen, de Jong Bouke C
Abstract excerpt
The majority of Mycobacterium tuberculosis isolates resistant to isoniazid harbour a mutation in katG. Since these mutations cause a wide range of minimum inhibitory concentrations (MICs), largely below the serum level reached with higher dosing (15 mg/L upon 15-20 mg/kg), the drug might still remain partly active in presence of a katG mutation. We therefore investigated which genetic mutations predict the level...
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