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Article

Insulin and insulin-like growth factor-1 binding specificity is determined by distinct regions of their cognate receptors.

The Journal of biological chemistry - 15 Oct 1991

Schumacher R, Mosthaf L, Schlessinger J, Brandenburg D, Ullrich A

Abstract excerpt

Chimeric insulin/insulin-like growth factor-1 receptors and insulin receptor alpha-subunit point mutants were characterized with respect to their binding properties for insulin and insulin-like growth factor-1 (IGF-1) and their ability to translate ligand interaction into tyrosine kinase activation in intact cells. We found that replacement of the amino-terminal 137 amino acids of the insulin receptor (IR) with...

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PMID: 1655782

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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