Article
Insulin and insulin-like growth factor-1 binding specificity is determined by distinct regions of their cognate receptors.
The Journal of biological chemistry - 15 Oct 1991
Schumacher R, Mosthaf L, Schlessinger J, Brandenburg D, Ullrich A
Abstract excerpt
Chimeric insulin/insulin-like growth factor-1 receptors and insulin receptor alpha-subunit point mutants were characterized with respect to their binding properties for insulin and insulin-like growth factor-1 (IGF-1) and their ability to translate ligand interaction into tyrosine kinase activation in intact cells. We found that replacement of the amino-terminal 137 amino acids of the insulin receptor (IR) with...
Topics
- Base Sequence
- Cell Line
- Chimera
- Cysteine
- Humans
- Insulin
- Insulin-Like Growth Factor I
- Ligands
- Molecular Sequence Data
- Mutation
- Phosphorylation